Journal Gazette from Mattoon, Illinois • Page 2

A-X-lfAttooo, (a) Jmral Guett-lluridtjr, September 1967 CHaolesteroHoweriiiig drag major advance ticular natient. officials of the Dharmaceuticaf company said the new drug, to be! sold under tne Drana name will be available in drug; tim in two or three weeks. tended only for patients whose 1 cholesterol put them at significant risk of developing cardiovascular disease and who have not responded to diet and exercise. However, doctors can prescribe any drug however they see fit once it wins FDA and the decision on when to turn to lovastatin tablets for a particular patient will remain with the doctor. "Diet will remain the cor nerstone of treatment for the majority of patients," said Antonio Gotto, chairman of the Lipid Research Clinic at the Baylor College of Medicine in Texas.

But he acknowledged at a news conference sponsored by, lovastatin's manufacturer, Merck Sharp Dohme, that the "greatest risk of misuse" of the drug will come from doctors who turn to it before being certain that diet and exercise are not working for a par Tbey" said the cost to the phafi: macy will be $1.25 per tablet, con; cMpred the dailv dose for most tients. The actual price to the tient wui vary, uepenuing on retail markup placed on WASHINGTON (AP) The commissioner the Food and Drug Administration has nailed a new drug that reduces cholesterol levels as a major advance that may reduce the risk of heart disease in millions of Americans. Dr. Frank Young said combining the new drug, lovastatin, which received FDA approval and will be on the market in two to three weeks, with diet and exercise may reduce the chance of heart disease. fThis therapy combines the bert tlat we try to bring and diet and then the appropriate use of medicine when required," Young said on NBC-TV's "Today" show.

"''Certainly we should all change our lifestyles our caloric intake if we have high cholesterol problems, increase our of diet is well established, and it should be used first." Havel commented in San Fran-' cisco, where his center was one of the 'facilities that began clinical' trials of lovastatin in 1984. The drug has special meaning for the estimated 400,000 Americans who suffer from a genetic defect that renders their bodies incapable of maintaining a proper level of cholesterol no matter how healthy their lifestyles. Cholesterol occurs in all foods of animal origin and also is manuf ac-tuered in the body by the liver. It is essential to bodily functions, but too much in the blood results in deposits along the walls of the arteries which can restrict blood flow and, if serious enough, result in heart attack or stroke. The FDA instructions accompanying lovastatin will say it is in exercise and then, under the guidance of a doctor, use the appropriate medicine," Young said.

"I'd like to emphasize that this realy is a major advance. It does block the synthesis of cholesterol early and we think it's a very important drug." The availability of such a treatment offers an alternative to physicians whose patients are at high risk of heart attack and stroke because of too much cholesterol in their blood. "Lovastatin is more effective than a good diet," said Richard Havel, director of the Cardiovascular Research Institute at the University of California, San Francisco. "It can lower cholesterol by 30 to 40 percent," while diets currently recommended for wide use can only lower it perhaps 15 percent. But the safety by tne local arug store.

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